Author Archives: Dr Datta

Haemorrhoids (Piles) – All You Need To Know

Piles surgery in Hyderabad: Haemorrhoids are blood vessels in the anal canal, they are present circumferentially in the anal canal but mainly located at the 3, 7, and 11 O clock positions of the anal canal. There are internal haemorrhoids inside the anal canal and external haemorrhoids covered by skin and are mainly located outside the anal canal.

Internal haemorrhoids: These are inside the anal canal and are covered by mucosa. They are small and are called haemorrhoidal cushions and are part of the normal anal continence mechanism. They are the ones that bleed when one passes stools.  They can also enlarge and prolapse outside the anal canal and cause a lot of problems.

External haemorrhoids: These are situated outside the anal canal and are covered by skin. They generally don’t bleed but they are prone to clotting, a condition called thrombosed external haemorrhoids.

What causes haemorrhoids?

Haemorrhoids are blood vessels and have no valves. Raising intra-abdominal pressure, straining while passing stools, constipation, spending a lot of time in the toilet and lack of fiber in the diet, spending a long time in a toilet to pass stools, etc are some of the reasons for haemorrhoids.

What are the symptoms of haemorrhoids?

  1. Blood in stools– painless, bright red blood while passing stools is the most common symptom. The blood is bright red and not mixed with stool, it is separate from the stools and it splashes into the commode. The bleeding can be severe and continuous in some cases.
  2. Prolapse– the piles enlarge with time and come out of the anal canal; this is called prolapsing haemorrhoids. They either go back inside the anus after passing stools (Grade II Haemorrhoids) or need to be pushed inside (Grade III). Some large ones do not go back and stay outside the anal canal only (Grade IV).
  3. Itching– When haemorrhoids prolapse and do not go in, they cause itching around the anal canal.
  4. Pain– the external haemorrhoids when they suddenly form a clot, i.e., thrombosed external haemorrhoids, cause a lot of pain. There is a painful swelling at the anal opening.

What are the Grades of Haemorrhoids? Grafing of the Haemorrhoids helps assess the severity and also guides the treatment. The Haemorrhoids are graded as follows:

  1. Grade I– they are inside the anal canal and do not come out
  2. Grade II– they come outside the anal canal, but go inside completely by themselves after the stool is passed
  3. Grade III– They come outside the anal canal but do not go back, they have to be pushed inside the anal canal after passing stools.
  4. Grade IV: these are always outside the anal canal

What are the complications of Haemorrhoids?

  1. Anaemia – prolonged bleeding piles can cause anemia (low haemoglobin). Anaemia causes fatigue, tiredness, feeling low, and in extreme cases, heart failure.
  2. Strangulation: the haemorrhoids sometimes can come out of the anal canal and get stuck and do not go inside again. This happens when you strain.  They become swollen, congested, and painful. This is an emergency condition and needs immediate hospitalization and treatment.
  3. Thrombosis of external haemorrhoids: the external haemorrhoids may clot and cause painful swelling at the anus.

What are the non-surgical measures to prevent bleeding from the haemorrhoids?

All those with haemorrhoids do not need surgery. Many of them can be managed with medications and some lifestyle modifications. The following measures should be taken:

  1. Do not strain while passing stools– straining puts pressure on the haemorrhoids and the haemorrhoids tend to get bigger with time when you strain and they start coming out of the anus. They also bleed more when you strain or put pressure to pass stools.
  2. Do not spend too much time on the toilet:  spending lot of time in the toilet to pass stools, using your mobile or reading a newspaper in the toilet, waiting for the bowel movement to happen, not addressing constipation, straining to pass stools are very bad habits and they worsen your piles. The piles will enlarge and starting prolapsing.
  3. Diet rich in fibre– a high fibre diet rich in vegetables, green leafy vegetables taken regularly will prevent constipation. Passing soft stools daily without straining prevents bleeding from the haemorrhoids. Hard stools cause friction with the haemorrhoids
  4. Treat constipation- if you are constipated, discuss this with your doctor, and take high-fibre diet and other measures to resolve constipation.  Addressing constipation is the single most important measure which reduces the bleeding from piles and prevents the worsening of piles.
  5. Drink plenty of water: drinking adequate water, at least 3 liters in a day, is known to prevent constipation and bleeding from hemorrhoids.
  6. Regular exercise: regular exercise is a natural laxative, improves your digestion keeps the bowel moving, and helps your constipation.
  7. Laxatives: Bulk laxatives like Isabgul and poly ethylene glycol along with some stimulant laxatives (like Sodium Pico sulfate) and liquid paraffin are used for a week or two to address the constipation and reduce bleeding. We do not recommend long-term usage of laxatives as they can cause dependence.
  8. Medications: Flavonoids (like Daflon), calcium dobesilate, etc., are a few medications that when taken are known to reduce the severity of piles and bleeding from piles.

When to go for piles surgery in Hyderabad?

Not all patients with haemorrhoids need surgery. Many will improve with medical measures and may not bleed again if these measures are followed strictly and consistently. However, many patients continue to bleed despite following all non-operative and medical measures. Then one must one must consider surgery. One should go for surgery if:

  1. Continuous bleeding not improving with medical and lifestyle measures
  2. Patients with anaemia
  3. Patients with prolapsing haemorrhoids, Grade II, II, and IV haemorrhoids where the haemorrhoids come out of the anal canal,
  4. Patients with strangulation- this can recur and the piles have to be addressed surgically. The irreducible and strangulated piles are initially treated with medical measures to reduce the prolapse and congestion and later taken up for surgery once the swelling and bleeding have subsided.

What is the best surgery for Haemorrhoids?

There are many surgeries and treatment methods for piles. The type of surgery depends on the grade of piles.

1) Sclerotherapy– for very early piles, Sclerotherapy helps, this is an outpatient procedure, and sclerosing agents like Polidocanol, STD, etc are injected into and around the piles. The scar forms around the piles and they stop bleeding. This is done for very small and early piles.

2) Banding of the piles: rubber bands are applied over the piles with a band applicator. The piles fall off in a few days and get scarred. This is an outpatient procedure. This is done for very early and small piles.

3) Open haemorrhoidectomy: this is one of the earliest surgical procedures for piles. This is called the Milligan Morgan haemorrhoidectomy. The piles are removed/ excised completely. This is painful procedure is not preferred nowadays as there are many other painless options.

4) Stapler haemorrhoidectomy: This is a very good procedure for prolapsing Haemorrhoids. This is called as PPH or MIPH, standing for Procedure for prolapsed haemorrhoids or minimally invasive procedure for Haemorrhoids. This is a relatively painless, short hospital stay procedure, ideal for patients with large and prolapsing high-grade hemorrhoids. A circular strip of rectal mucosa above the anal canal is excised circumferentially with the help of a circular stapler. The prolapsing piles get fixed up inside the anal canal and the blood supply to the piles is cut off. This is a very good procedure for piles of all grades but is very often done for Grade II, III, and IV piles. This is very helpful for patients who have large circumferential piles.

5) Laser surgery for piles: this is the latest of all and is a relatively painless procedure, with no wounds and fast recovery suitable for all grades of piles, but lower-grade piles respond better. Laser heat energy is used to coagulate the piles which later shrink due to fibrosis and scar formation. This has many advantages like – less pain after a procedure, outpatient procedure, and fast recovery after the surgery.

What is the duration of Hospital stay and time to recovery after a haemorrhoid operation?

Most of the surgical procedures for Haemorrhoids are either daycare procedures (same-day discharge) or overnight stays in the Hospital. The recovery is good and fast as most of the procedures performed now are relatively pain-free and one can resume work and office within 3-4 days.

What are the measures or precautions to be taken after surgery?

After surgery, the patient is advised to follow this advice:

  1. Diet rich in fiber – a high-fiber diet like green salads, green leafy vegetables, fruits, oats, etc is to be taken to ensure bulky and smooth stools, to reduce pain and discomfort after surgery.
  2. Laxatives– Laxatives like Isabel, PEG (polyethylene glycol), and Liquid paraffin are routinely prescribed to all patients for a few days after the surgery to prevent constipation and to ensure a smooth passage of stool without pain or discomfort.
  3. Sitz bath– sitz bath is sitting in a tub of warm water and wetting the anal region in warm water for 10-15 min each time and 3-4 times a day. This is soothing and relieves swelling and discomfort after surgery. This is continued for a week or two after surgery.
  4. Avoid straining while passing stools- do not strain while passing stools.

Analgesics- some patients may need mild analgesics like paracetamol to relieve discomfort and pain after surgery.

Pancreatic Cancer – Surgical Treatment Can Help!

Pancreatic cancer is a type of cancer that starts as an abnormal growth of cells in the pancreas. The pancreas is situated behind the lower part of the stomach. Enzymes and hormones that help digest food and help control blood sugar are made in the pancreas.

The most common type of pancreatic cancer is pancreatic ductal adenocarcinoma.

It is rarely found at an early stage when the chances of getting cured are higher. This is because the symptoms take time to manifest until then the cancer has spread to different organs.

Pancreatic cancer treatment in Hyderabad: The options for pancreatic cancer include – surgery, chemotherapy, and radiation therapy.

Symptoms 

Pancreatic cancer doesn’t cause any symptoms until the disease is advanced. Signs and symptoms of pancreatic cancer are as follows-

  • Loss of weight
  • Loss of appetite
  • Itching
  • Diabetes
  • Swelling and pain in arms or legs
  • The pain could be due to a blood clot
  • Weakness
  • Tiredness
  • Jaundice

Causes

There is no particular cause that has been found for pancreatic cancer. Medical professionals and doctors have found some reasons that may raise the risk of this cancer. These reasons include- having a family history of pancreatic cancer or smoking.

Risk factors

Factors that may raise the risk of pancreatic cancer are as follows –

  • Type 2 diabetes
  • Smoking
  • Pancreatitis (which is also known as chronic inflammation of the pancreas)
  • A family history of DNA changes increases cancer risk. These include changes in the BRCA2 gene, familial atypical multiple mole melanoma (FAMMM) Syndrome, and Lynch syndrome.
  • Family history of pancreatic cancer
  • Obesity

Complications

As pancreatic cancer grows and spreads it causes complications like

Loss of weight – Various people with pancreatic cancer lose weight as this type of cancer uses more of the body’s energy.

Vomiting and nausea caused by treatment of this cancer or cancer pressing on the belly might make it difficult to eat.

This type of cancer blocks the liver’s bile duct which can cause jaundice. Yellowing of skin and the whites of the eyes are some of the signs. Jaundice can cause pale stools and dark-colored urine. It usually occurs without stomach pain.

If the bile duct is blocked, a metal or plastic tube called a stent is put inside. This stent helps to hold the bile duct open. All this is done using a procedure called endoscopic retrograde cholangiopancreatography which is also called ERCP.

During ERCP, a gastroenterologist puts a long tube with a small camera called an endoscope down the throat. This tube goes down through the stomach and into the upper part of the intestine (small intestine). The doctor also put a dye into the pancreatic ducts and bile ducts through a tiny tube that fits through the endoscope. The dye helps to show up the ducts on imaging tests.

Pain- an aggressively growing tumor might press on nerves present in your abdomen. Causing a severe pain. Treatments such as chemotherapy and radiation might help to slow the tumor’s growth and help reduce the pain.

If medicines aren’t helping. Doctors suggest a celiac plexus block. This procedure uses a needle to put alcohol in the nerves that control pain in the stomach. The alcohol infused in the nerves stops the nerves from sending pain signals to the brain.

Bowel blockage – pancreatic cancer can grow on the first part of the small intestine known as the duodenum. Which can block the flow of digested food from the stomach into the intestines.

When to see a surgical gastroenterologist who specializes in pancreatic cancer surgery?

Visit a surgical gastroenterologist if you have the symptoms that are bothering you.

Pancreatic Cancer Treatment in Hyderabad

The best and the only reliable option to cure pancreatic cancer is surgery.

It is possible to remove or resect all cancer when test results indicate potentially curative surgery. But, if the cancer has widespread, then palliative surgery is done to prevent complications and to get rid of symptoms.

Only 20% of pancreatic cancers remain confined to the pancreas when they are first diagnosed. In most cases, complete resection becomes difficult when the cancer spreads too far away.

Surgical Treatment for Pancreatic Cancer

Whipple procedure (pancreaticoduodenectomy)

The most common and reliable procedure to remove pancreatic cancer is pancreaticoduodenectomy (Whipple procedure). In this procedure, an expert surgeon removes the head part of the pancreas or the body of the pancreas. Sometimes, a part of the small intestine, bile duct, lymph nodes, and gallbladder are removed.

Learn more about the “Whipple Procedure”

It can be done in both ways: open as well as laparoscopically.

Distal pancreatectomy

Pancreatic cancer confined to the body and tail of the pancreas is removed by a distal pancreatectomy procedure. Speen is also removed (splenectomy) during this procedure.

Total pancreatectomy

This operation removes the entire pancreas, the gallbladder and common bile duct, part of the stomach and small intestine, and the spleen.

Prevention 

Screening is done for people with a greater risk of pancreatic cancer. Screening uses tests to look for signs of pancreatic cancer that do not show any symptoms. Screening involves imaging tests such as ultrasound and MRI.

The main objective of screening is to find whether the pancreatic cancer is small or can be cured.

Another type of testing known as genetic testing is done to find DNA changes that run in families and increase the risk of pancreatic cancer.

Ways to lower the risk of pancreatic cancer

Stop smoking- If you smoke, then talk to a specialist about the ways and therapies to stop smoking. Some of the potential therapies might include nicotine replacement therapy and medicines.

Maintain a healthy weight. Exercise regularly. Choose a vegetable-rich diet with fruits and whole grains in smaller amounts.

Stop consuming alcohol

If you are looking for the best pancreatic cancer treatment in Hyderabad, then meet Dr. Datta Ram U.

Understanding Jaundice: Causes and Symptoms

Jaundice, characterized by the yellowing of the skin, eyes, and mucous membranes, is a common medical condition with various underlying causes. While it is often a symptom of an underlying health issue rather than a disease itself, understanding the causes of jaundice is essential for proper diagnosis and treatment. In this article, we will explore the primary causes of jaundice and discuss the associated symptoms and complications.

Jaundice Causes and Symptoms

Hepatitis

Hepatitis, inflammation of the liver, is one of the leading causes of jaundice. Viral hepatitis, including hepatitis A, B, C, D, and E viruses, can infect the liver and impair its function, leading to jaundice. Hepatitis viruses are typically transmitted through contaminated food or water (hepatitis A and E) or blood and bodily fluids (hepatitis B, C, and D). Other causes of hepatitis include alcohol abuse, autoimmune hepatitis, and drug-induced liver injury.

Liver Cirrhosis

Liver cirrhosis is a chronic liver disease characterized by the gradual replacement of healthy liver tissue with scar tissue, impairing liver function over time. Chronic alcohol abuse, viral hepatitis, nonalcoholic fatty liver disease (NAFLD), and autoimmune liver diseases are common causes of liver cirrhosis. As liver function declines, jaundice may develop as a result of impaired bilirubin processing and clearance.

Gallstones

Gallstones are hardened deposits that form in the gallbladder, a small organ located beneath the liver. When gallstones obstruct the bile ducts, which transport bile from the liver to the intestines, bile flow may become obstructed, leading to jaundice. Gallstone-related jaundice is often accompanied by symptoms such as abdominal pain, nausea, vomiting, and fever.

Bile Duct Obstruction

Obstruction of the bile ducts can occur due to various factors, including gallstones, tumors, inflammation, or scarring of the bile ducts. When bile flow is obstructed, bilirubin accumulates in the bloodstream, resulting in jaundice. Bile duct obstruction may be caused by conditions such as pancreatic cancer, bile duct cancer, primary sclerosing cholangitis, or choledocholithiasis (gallstones in the bile duct).

Hemolytic Anemia

Hemolytic anemia is a condition characterized by the premature destruction of red blood cells, leading to an increased production of bilirubin. When the liver is unable to process the excess bilirubin efficiently, jaundice may occur. Hemolytic anemia can be caused by various factors, including autoimmune disorders, genetic conditions, infections, medications, and toxins.

Liver Cancer

Liver cancer, also known as hepatocellular carcinoma, can cause jaundice as it progresses and impairs liver function. Risk factors for liver cancer include chronic viral hepatitis, liver cirrhosis, alcohol abuse, obesity, and exposure to certain toxins and carcinogens. Jaundice associated with liver cancer may be accompanied by symptoms such as abdominal pain, weight loss, fatigue, and loss of appetite.

Gilbert’s Syndrome

Gilbert’s syndrome is a benign genetic condition characterized by mild jaundice that occurs intermittently, often in response to stress, fasting, or illness. In Gilbert’s syndrome, there is a deficiency of an enzyme called UDP-glucuronosyltransferase, which is involved in the conjugation and processing of bilirubin in the liver. While Gilbert’s syndrome does not typically cause serious health problems, it can result in mild jaundice and elevated bilirubin levels.

Symptoms of Jaundice

In addition to yellowing of the skin, eyes, and mucous membranes, jaundice may be accompanied by other symptoms, depending on the underlying cause. Common symptoms of jaundice include:

  • Yellowing of the whites of the eyes (scleral icterus)
  • Dark urine
  • Pale stools
  • Abdominal pain or discomfort
  • Nausea and vomiting
  • Fatigue and weakness
  • Fever
  • Unintentional weight loss

Complications of Jaundice

Untreated jaundice can lead to complications such as:

  • Liver failure
  • Bleeding disorders
  • Encephalopathy (brain dysfunction)
  • Increased risk of infections
  • Malnutrition
  • Kidney failure

Conclusion

Jaundice is a common medical condition that can result from various underlying causes, including liver disease, gallstones, bile duct obstruction, hemolytic anemia, and liver cancer. Recognizing the symptoms of jaundice and identifying its underlying cause, is essential for proper diagnosis and treatment. If you or someone you know experiences jaundice or related symptoms, seek medical attention promptly to determine the cause and receive appropriate care. Early diagnosis and treatment can help prevent complications and promote recovery.

Understanding Alcoholic Liver Disease: Symptoms, and Treatment

Alcoholic liver disease (ALD) is a serious condition that arises due to excessive alcohol consumption over a prolonged period. At its core, ALD encompasses a range of liver disorders, including fatty liver, liver fibrosis, and cirrhosis. Let us try to understand the progression of ALD, shedding light on its causes, symptoms, and available treatment options.

Causes of Alcoholic Liver Disease

ALD primarily stems from the toxic effects of alcohol on the liver. When alcohol is consumed, it is metabolized in the liver, leading to the production of harmful by-products that can damage liver cells. Chronic alcohol abuse overwhelms the liver’s ability to metabolize alcohol efficiently, resulting in inflammation, oxidative stress, and ultimately, liver damage.

Additionally, individual susceptibility to ALD varies based on several factors, including:

Genetics: Certain genetic factors can predispose individuals to ALD, making them more vulnerable to liver damage even with moderate alcohol consumption.

Duration and Quantity of Alcohol Intake: The risk of developing ALD increases with prolonged and excessive alcohol consumption. Both the amount and duration of alcohol intake play crucial roles in determining the extent of liver damage.

Nutritional Factors: Poor nutrition, particularly deficiencies in essential vitamins and minerals, can exacerbate the harmful effects of alcohol on the liver, accelerating the progression of ALD.

Symptoms of Alcoholic Liver Disease

ALD often progresses silently, with symptoms becoming apparent only in later stages when significant liver damage has occurred. However, recognizing the signs of ALD is crucial for early intervention and management. Common symptoms of ALD include:

Fatigue: Persistent tiredness and weakness, even after adequate rest.

Abdominal Pain: Discomfort or pain in the upper right abdomen, indicative of liver inflammation or enlargement.

Jaundice: Yellowing of the skin and eyes due to impaired liver function and bilirubin accumulation.

Swelling: Edema, or fluid retention, particularly in the legs and abdomen, resulting from liver dysfunction.

Nausea and Vomiting: Persistent feelings of nausea and episodes of vomiting, often accompanied by loss of appetite.

Mental Confusion: Cognitive impairment, confusion, or difficulty concentrating, indicating advanced liver damage.

Diagnosis and Treatment Options

Diagnosing ALD typically involves a comprehensive evaluation of medical history, physical examination, and diagnostic tests, including blood tests, imaging studies, and liver biopsy.

Once diagnosed, the treatment approach for ALD focuses on:

Alcohol Cessation: The cornerstone of ALD management involves complete abstinence from alcohol to prevent further liver damage and promote liver regeneration.

Nutritional Support: Nutritional therapy, including supplementation with vitamins and minerals, is essential to address deficiencies and support liver function.

Medications: In certain cases, medications may be prescribed to manage complications of ALD, such as inflammation, infection, or fluid retention.

Liver Transplantation: In advanced cases of ALD where liver function is severely compromised, liver transplantation may be considered as a life-saving intervention.

Preventing Alcoholic Liver Disease

Prevention is key when it comes to ALD, and adopting healthy lifestyle choices can significantly reduce the risk of developing this debilitating condition. Strategies for preventing ALD include:

Moderate Alcohol Consumption: Limiting alcohol intake to within recommended guidelines can mitigate the risk of ALD and other alcohol-related liver disorders.

Balanced Nutrition: Maintaining a well-balanced diet rich in fruits, vegetables, whole grains, and lean proteins can support overall liver health and minimize the impact of alcohol on the liver.

Regular Exercise: Engaging in regular physical activity can help maintain a healthy weight and reduce the risk of liver damage associated with obesity and sedentary lifestyles.

Routine Health Screenings: Regular health check-ups and screenings can aid in the early detection and management of liver-related conditions, including ALD.

Bottom Line

In conclusion, alcoholic liver disease is a serious yet preventable condition that requires awareness, timely intervention, and lifestyle modifications. By understanding the causes, recognizing the symptoms, and adopting preventive measures, individuals can safeguard their liver health and reduce the burden of ALD on both individuals and healthcare systems.

Recovery after Hernia Surgery

Hernia surgery is a common medical procedure that aims to repair a protrusion of an organ or tissue through a weakened area of the abdominal wall. While the surgery is often routine, the recovery process plays a crucial role in ensuring a smooth and successful outcome. Understanding what to expect and how to navigate the postoperative period is essential for patients undergoing hernia surgery.

Immediate Postoperative Period

In the immediate aftermath of hernia surgery, patients are typically monitored in a recovery area before being discharged. It is common to experience some discomfort, swelling, and bruising around the surgical site. Pain management is a critical aspect of this phase, and medications prescribed by the surgeon should be taken as directed to alleviate any discomfort.

Recovery at Home

Upon returning home, patients are advised to follow specific guidelines to promote healing and prevent complications. These guidelines often include restrictions on lifting heavy objects, engaging in strenuous activities, and avoiding certain body movements that could strain the surgical site. Rest and allowing the body time to heal are paramount during this initial recovery period.

Diet and Hydration

Maintaining a healthy and balanced diet is crucial for a successful recovery after hernia surgery. Patients are generally encouraged to consume fiber-rich foods to prevent constipation, which can be a common side effect of both surgery and pain medications. Staying hydrated is equally important, aiding in overall healing and preventing complications.

Gradual Resumption of Activities

As the days pass, patients can gradually increase their level of activity. Walking is often recommended as a low-impact exercise that promotes circulation and aids in recovery. However, it’s essential to listen to the body and avoid overexertion. Returning to work and normal daily activities should be done in consultation with the surgeon, ensuring that the individual’s specific case is considered.

Follow-up Appointments

Regular follow-up appointments with the surgeon are integral to monitoring the recovery progress. During these visits, the surgeon will assess the healing of the incision site, address any concerns the patient may have, and provide further guidance on resuming normal activities. Patients must attend these appointments and communicate openly with their healthcare team.

Managing Pain and Discomfort

Pain management remains a crucial aspect of recovery, and patients should adhere to the prescribed pain medications. Over-the-counter medications, such as acetaminophen or ibuprofen, may be recommended by the surgeon for milder discomfort. It’s essential to strike a balance between managing pain effectively and avoiding excessive reliance on medications.

Watch for Warning Signs

While discomfort and mild pain are expected after hernia surgery, it’s crucial to be vigilant for any signs of complications. Persistent and severe pain, redness, swelling, or discharge from the incision site should prompt immediate medical attention. Additionally, any signs of infection, such as fever, should be reported to the healthcare provider promptly.

Physical Therapy and Rehabilitation

In some cases, the surgeon may recommend physical therapy to aid in the recovery process. Targeted exercises can help strengthen the abdominal muscles and improve overall flexibility. Engaging in a rehabilitation program can contribute to a quicker return to normal activities and reduce the risk of recurrence.

Conclusion

Recovery after hernia surgery is a gradual process that requires patience, adherence to medical guidance, and close communication with healthcare providers. By following postoperative instructions, managing pain effectively, and staying vigilant for any warning signs, patients can navigate the path to recovery successfully. Each individual’s recovery journey is unique, and personalized care is key to achieving the best possible outcome after hernia surgery.